niPOC - specialist

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niPOC
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What is the niPOC test on pregnancy remains?

niPOC is an advanced non-invasive test which uses a blood test to determine whether a pregnancy loss was caused by a chromosome abnormality.
Innovative application of non-invasive analysis of circulating foetal DNA for miscarriages.

Why is it so important?

50% of miscarriages in the first term are due to chromosomal abnormalities.
This figure rises to 60% in the case of women who receive assisted reproductive treatment and further increases with age.
24 chromosomes are screened to identify the reason for the miscarriage.
The information provided by the niPOC test can help patients make future decisions on their reproductive health and maximize the probability of a successful pregnancy and reduce the likelihood of another miscarriage.

What is the procedure of the non-invasive POC test?

*This step must be performed first, before spontaneous expulsion, suction evacuation, curettage, or administration
of drugs to treat the expulsion or retained product of conception.

Benefits of the niPOC test

The genetic study is a valuable tool to determine the cause of the miscarriage and offer reproductive counselling to the couple. It has been widely demonstrated that knowing the cause of the miscarriage leads to greater comfort and peace of mind for the patients.
Informative results in >85%
Results in 3-7 working days.
The 24 chromosomes are analysed to pinpoint why the miscarriage occurred
No maternal cell contamination (MCC)
By performing the study on a blood sample, it avoids any medical complications resulting from obtaining a sample by surgical means

Why niPOC?

Who is the niPOC test on pregnancy remains for?

It is suitable for anybody who has had a miscarriage*.
It is particularly beneficial to patients who have had recurrent miscarriages or for couples/women who are undergoing assisted reproductive treatment.

Limitations of the niPOC test on pregnancy remains

This method does not detect balanced structural chromosomal abnormalities and might not detect the following: aneuploidy in low-level mosaicism; triploids/tetraploids; uniparental disomy; and deletions or duplications inferior to 7 Mb.
Approximately 15% non-informative results due to insufficient quantity or quality of DNA

*This step must be performed first, before spontaneous expulsion, suction evacuation, curettage, or administration of drugs to treat the expulsion or retained product of conception

(Martinez et al., 2010; Campos-Galindo et al., 2012)

Documentación

Specialist

Scientific evidence

Relevant studies on POC tests on pregnancy remains:

Campos-Galindo I, García-Herrero S, Martínez-Conejero JA, Ferro J, Simón C, Rubio C. Molecular analysis of products of conception obtained by hysteroembryoscopy from infertile couples. J Assist Reprod Genet. 2015 May;32(5):839-48. doi: 10.1007/s10815-015-0460-z. Epub 2015 Mar 17. PMID: 25779005; PMCID: PMC4429442.
Martínez MC, Méndez C, Ferro J, Nicolás M, Serra V, Landeras J. Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment. Fertil Steril. 2010 Jan;93(1):289-92. doi: 10.1016/j.fertnstert.2009.07.989. Epub 2009 Sep 11. PMID: 19748088.
Al-Asmar N, Oral presentation ESHRE 2019. Simón, C., & Rubio, C. (Eds.). (2022). Handbook of Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health (2nd ed.). CRC Press. https://doi.org/10.1201/9781003024941
Colley E, Devall AJ, Williams H, Hamilton S, Smith P, Morgan NV, et al. Cell-Free DNA in the Investigation of Miscarriage. J Clin Med. 2020;9(11).
Clark-Ganheart CA, Fries MH, Leifheit KM, Jensen TJ, Moreno-Ruiz NL, Ye PP, et al. Use of cell-free DNA in the investigation of intrauterine fetal demise and miscarriage. Obstet Gynecol. 2015;125(6):1321-9.
Yaron Y, Pauta M, Badenas C, Soler A, Borobio V, Illanes C, et al. Maternal plasma genome-wide cell-free DNA can detect fetal aneuploidy in early and recurrent pregnancy loss and can be used to direct further workup. Hum Reprod. 2020;35(5):1222-9.
Schlaikjær Hartwig T, Ambye L, Gruhn JR, Petersen JF, Wrønding T, Amato L, et al. Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study. Lancet. 2023;401(10378):762-71.
Peng S, Bhatt S, Borrell A, Yaron Y. Economic impact of using maternal plasma cell-free DNA testing to guide further workup in recurrent pregnancy loss. Prenat Diagn. 2021;41(10):1215-21.
Balaguer N, Rodrigo L, Mateu-Brull E, Campos-Galindo I, Al-Asmar N, Rubio C, Milán M. Cell-free DNA-based non-invasive approach for the diagnosis of clinical miscarriage: a retrospective study. BJOG.2023 (Under review).

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A miscarriage occurs En el 25% of all pregnancies

50% of miscarriages in the first term are due to chromosomal abnormalitiess

This increases to 60%among women who have received assisted reproductive treatment

Other analysis methods require cell culture and results can take up to 4 weeks.

What is the niPOC test on pregnancy remains?

Why is it so important?

What is the procedure of the non-invasive POC test?

Benefits of the niPOC test

Why niPOC?

Who is the niPOC test on pregnancy remains for?

Limitations of the niPOC test on pregnancy remains

Relevant studies on POC tests on pregnancy remains:

POC

Igenomix and fertility

ERA

PGT-A

EndomeTRIO

Igenomix is in the media

Non-invasive niPOC test for miscarriage

niPOC is an advanced non-invasive test which uses a blood test to determine whether a pregnancy loss was caused by a chromosome abnormality.

A miscarriage occurs En el 25% of all pregnancies

50% of miscarriages in the first term are due to chromosomal abnormalitiess

This increases to 60%among women who have received assisted reproductive treatment

Other analysis methods require cell culture and results can take up to 4 weeks.

What is the niPOC test on pregnancy remains?

Why is it so important?

What is the procedure of the non-invasive POC test?

Benefits of the niPOC test

Why niPOC?

Who is the niPOC test on pregnancy remains for?

Limitations of the niPOC test on pregnancy remains

Relevant studies on POC tests on pregnancy remains:

POC

Igenomix and fertility

Other services

ERA

PGT-A

EndomeTRIO

Igenomix is in the media