The Sperm Aneuploidy Test (SAT) is a test to study the genetic factor of male infertility.
It allows for the evaluation of the presence of an abnormal number of chromosomes (aneuploidy and diploidy) in the sperm.
The chromosomes 13, 18, 21, X and Y, are most frequently implicated in spontaneous miscarriages and affected offspring with chromosomal abnormalities. In SAT, these chromosomes are analysed by fluorescence in situ hybridization (FISH).
An increase of sperm chromosomal abnormalities affects your reproductive journey at three levels:
EMBRYO LEVEL:
Rodrigo et al., 2010.
PREGNANCY LEVEL:
Rubio et al., 2001.
OFFSPRING LEVEL:
Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril. 2010 Sep; 94(4):1380-6.
Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod. 2001 Oct; 16(10):2084-92.
Rodrigo L, Mateu E, Mercader A, Cobo A, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S, Mir P, Simón C, Rubio C. New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization. BioMed
Research International. 2014; In Press.
Sex selection and Sex determination, before and after conception is prohibited and punishable under PC & PNDT act no. 57 of 1994
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