22 September 2016

Are you experiencing multiple implantation failures during IVF? A wrong window of implantation (WOI) could be the reason

There are times when women opting for assisted methods of achieving pregnancy are disappointed because they don’t get any positive result. This mostly...


There are times when women opting for assisted methods of achieving pregnancy are disappointed because they don’t get any positive result. This mostly happens in case of a weak embryo or because the embryo is transferred when the Endometrium is not receptive, which means that the embryo is transferred in the wrong ‘window of implantation’. Endometrium is the inner lining which prepares every month to accept the embryo, this is the place where the embryo implants and resides during gestation. Endometrial receptivity is a state when the Endometrium is ready for embryo implantation which leads to a successful pregnancy. In cases of natural conception this is between 19th-21st day of the menstrual cycle.

Analysing and detecting the window of implantation is really important so as to prevent implantation failures. Due to lack of objective and accurate methods of assessment, endometrial receptivity (ER) is not usually investigated in an infertile patient or even before in-vitro fertilization (IVF). But Endometrial Receptivity Analysis (ERA) by IGENOMIX, determines whether the woman is receptive on the day, when the biopsy is performed. If the result is positive then that is the window of implantation for that particular patient.

About 26% of the patients with multiple implantation failures are due to a wrong Window of Implantation, while clinical studies in India have shown a 60% increase in the rate of successful pregnancies post Endometrial Receptivity Analysis (ERA)

Endometrial Receptivity Analysis (ERA) is a personalised genetic test that leads to a “personalised embryo transfer”(PET), a timing which is selected based on the test performed on an individual. In India around 2500 people have opted for ERA and around 12000 people around the world have gone for it, thus increasing the rate of successful implantation. In addition to that, ERA test has shown high sensitivity and specificity for detecting gene expression profiles associated with receptivity.

Topics: ivf failure, successful pregnancy, ERA, infertility, implantation failure

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