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Genetic Solutions > ERA

ERA® Endometrial Receptivity Analysis

Maximize the chances of pregnancy without losing valuable embryos

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

ERA is the only endometrial receptivity test supported by a RCT*.

3 out of 10 patients have their implantation window shifted**

Are you interested?

Request information

Overview

  • ERA
  • Benefits
  • Indications

What is the ERA® (Endometrial Receptivity Analysis) test?

  • ERA® test, developed and patented by Igenomix (PCT/ ES2009/000386), is a test designed to evaluate endometrial receptivity.  
  • ERA® is the first diagnostic test that determines each woman’s unique personalized embryo transfer timing, therefore synchronizing the embryo transfer with the individualized window of implantation.

What is the procedure?

Why choose ERA?

Launched in 2011, ERA was the first test of its kind, revolutionising endometrial diagnostics and laying the foundation for personalised fertility treatment. By identifying a woman’s unique window of implantation, it enables precise embryo transfer timing to optimise IVF success. Backed by robust clinitcal evidence, ERA remains the most advanced and trusted endometrial receptivity test available.

  1. Scientifically proven and well trusted

ERA is a proven solution for patients with RIF, powered by the most
scientific publications and the highest clinical success rates compared to any other endometrial receptivity test in the market. In fact, ERA is the only endometrial receptivity test backed by an RCT*. This RCT, involving 320 patients with RIF, demonstrated significantly improved reproductive outcomes—including nearly double the live birth rates—for patients who used ERA in combination with PGT-A, compared to those who used PGT-A alone.

  1. Precision timing for embryo transfer, maximizing your chances of success

Powered by AI, the ERA algorithm is not only based upon the endometrial biopsy data from over 200,000 women but integrates clinical outcomes from personalised embryo transfers guided by its results. Combining this with the most comprehensive gene panel available (248 genes), ERA delivers the most precise transcriptomic profiling and personalized
embryo transfer timing—maximising implantation success.

  1. Comprehensive support & expertise

Backed by a global team of endometrial experts, ERA is the trusted endometrial receptivity test used by over 3,000 clinics worldwide. Our comprehensive support network includes world-class scientific advisors, dedicated endometrial specialists, genetic counsellors, and in-house
clinicians—providing expert guidance to clinics and patients every step of the way.

* 2024 Barbakadze et al. Cureus 16(6): e62949. DOI 10.7759/cureus.62949

Who should use ERA® Endometrial Receptivity Analysis test?

  • ERA® test is indicated for patients with recurrent implantation failure

When is the second endometrial biopsy needed?

90 % of cases don’t need a second biopsy. The second biopsy is only required under two circumstances:

  • Patients with a “Pre-receptive” result needing 2 more days with progesterone.
  • Patients with a “Post-receptive” result

Test limitations

  • ERA Specialists' Documents

Brochure

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Download

Publications List

igenomix-fertility
Download

EndomeTRIO Manual

igenomix-fertility
Download

RCT Key Findings

igenomix-fertility
Download

Retraction of a meta analysis

igenomix-fertility
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Scientific evidence

References:

* Barbakadze et al., Assessment of theRole of Endometrial ReceptivityAnalysis in Enhancing AssistedReproductive Technology Outcomesfor Advanced-Age Patients. Cureus vol.16,6 e62949. 23 Jun. 2024,doi:10.7759/cureus.62949.

Key Studies

Visit the ERA insight Hub – International to download the complete ERA Publication List and explore all related studies.

  • Independent
  • Igenomix

Assessment of the Role of Endometrial Receptivity Analysis in Enhancing Assisted Reproductive Technology Outcomes for Advanced-Age Patients.

Barbakadze T, Shervashidze M, Charkviani T, et al.
Cureus. 2024;16(6):e62949. Published 2024 Jun 23. doi:10.7759/cureus.62949

The Clinical Efficacy of Personalized Embryo Transfer Guided by the Endometrial Receptivity Array/Analysis on IVF/ICSI Outcomes: A Systematic Review and Meta-Analysis.

Liu Z, Liu X, Wang M, Zhao H, He S, Lai S. et al
Front Physiol. 2022;13:841437. Published 2022 Apr 27. doi:10.3389/fphys.2022.841437

Comparison of the Effectiveness of Endometrial Receptivity Analysis (ERA) to Guide Personalized Embryo Transfer with Conventional Frozen Embryo Transfer in 281 Chinese Women with Recurrent Implantation Failure.

Jia Y, Sha Y, Qiu Z, Guo Y, Tan A, Huang Y. et al
Med Sci Monit. 2022;28:e935634. Published 2022 Mar 22. doi:10.12659/MSM.935634

Role of endometrial receptivity array in current implantation failure.

Samadhiya R, Swarnkar G, Singh A, Chittawar P.
Fertility Science and Research, 8(2), 180

Clinical outcomes following endometrial receptivity assessment-guided personalized euploid embryo transfer in patients with previous implantation failures.

Ruiz-Alonso, M., Gómez, C., Stankewicz, T. et al.
Scientific reports vol. 15,1 16967. 15 May. 2025, doi:10.1038/s41598-025-01056-5

A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF.

Simón, C., Gómez, C., Cabanillas, S., Vladimirov, I., Castillón, G., Giles, et al.
Reproductive BioMedicine Online, 2020; 41(3):402-415

The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.

Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.
Fertil Steril. 2013 Sep;100(3):818-24. doi: 10.1016/j.fertnstert.2013.05.004. Epub 2013 Jun 4. PMID:23756099

The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity.

Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alamá P, Garrido N, Pellicer A, Simón C.
Fertil Steril. 2013 Feb;99(2):508-17. doi: 10.1016/j.fertnstert.2012.09.046. Epub 2012 Oct 23. PMID:23102856

A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature.

Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C.
Fertil Steril. 2011 Jan;95(1):50-60, 60.e1-15. doi: 10.1016/j.fertnstert.2010.04.063. Epub 2010 Jul 8. PMID:20619403


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Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.

Learn more about Igenomix

Other services you may be interested

EndomeTRIO

A new dimension of endometrial health

More information

EMMA

Evaluates the endometrium at the microbiological level

More information

ALICE

Detects the bacteria causing chronic endometritis

More information

Sex selection and Sex determination, before and after conception is prohibited and punishable under PC & PNDT act no. 57 of 1994

Igenomix is in the media

IGENOMIX has not affiliated any news outlet or publication identified above. News coverage does not constitute an endorsement of IGENOMIX or its products

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  • We guide you
    • Fertility
    • Inherited diseases
    • Worry-free pregnancy
  • Reproductive Health
    • Specialists
      • SAT
      • CGT
      • PGT-A
      • PGT-M
      • PGS+ERA Synchrony
      • Embrace
      • ERA
      • EMMA
      • ALICE
      • Endometrio
      • Family POC
    • Patients
      • SAT
      • CGT
      • PGT-A
      • PGT-M
      • PGS + ERA Synchrony
      • Embrace
      • ERA
      • EMMA
      • Family POC
      • ALICE
      • Endometrio
  • Diagnostic
  • About us
    • Igenomix Research
    • About Igenomix
  • ACADEMY
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