Non-invasive analysis for chromosomal examination
1. What is NACE?
The NACE test is a non-invasive analysis for chromosomal examination. This means that it is completely safe for you and for your baby. To perform the test, all that’s needed is a small sample of blood drawn from your arm just like for any other routine blood test.
The NACE test uses advanced technology to compare foetal DNA with the mother’s DNA to detect certain abnormalities with great precision and reliability.
During pregnancy, a baby’s DNA mixes with its mother’s blood DNA. Progress in the ﬁeld of genetics makes it possible for us to detect this DNA in the mother’s blood and screen genetic data regarding the baby’s chromosomes.
2. What is NACE useful for?
The NACE test screens for chromosomal abnormalities in the baby. Human beings have 23 pairs of chromosomes with a total of 46 (two copies of each pair). The ﬁrst 22 pairs are numbered from 1 to 22. The last pair determines our sex. Girls have two X chromosomes and boys have one X chromosome and one Y chromosome. Health and development issues appear if there is a missing or extra chromosome.
When there is an additional copy of a chromosome (i.e. three copies instead of two), it is called a trisomy.
NACE detects with maximum accuracy foetuses with Down’s syndrome. Likewise, it detects other frequent chromosomal alterations (chromosomes 18, 13, X and Y) with an equally high reliability rate. It has a higher accuracy rate than 1st trimester biochemical marker screening techniques such as triple marker + double marker screening and ultrasound scan.
3. For whom is NACE indicated?
The NACE test is designed for all those women who want to rule out the presence of a speciﬁc chromosomal alteration in the foetus (chromosomes 21, 18, 13, X and Y) and don’t want to put their pregnancy at risk. It is recommended for all pregnant women, especially those above the age of 35.
The test can be performed as early as the 10th week of your pregnancy or 12th week (in case of twins).
NACE can be carried out on women whose pregnancy has been achieved by IVF techniques, including pregnancies with egg donation.
4.How to get the NACE test step by step
- Consult with your gynecologist.
- Call +91 11 6651 7800 to ask for the test kit.
- You will receive the NACE kit.
- A blood simple will be taken.
- Igenomix will collect the kit with your blood sample.
- Igenomix will deliver the test results within 15 working days.
1. What kind of results will I get?
The report will indicate if the pregnancy is at a high or low risk. Where there is a high risk of chromosomal alteration, we recommend you go for an Amniocentesis, which will be beared by Igenomix.
2. Which alternatives exist to NACE test?
1st trimester screening
It is an examination that combines a scan and hormonal analysis taking the mother’s age into account. It is conducted between weeks 9 and 13 of a pregnancy.
It is performed at different times during a pregnancy and Down’s, Edwards and Patau syndromes can be suspected from it. A diagnostic test is needed to conﬁrm this result.
It is performed at week 15 using a sample of amniotic liquid. It is an invasive test with a 0.5-1% risk of miscarriage.
Similar to amniocentesis, this is an invasive test with a 1-2% risk of miscarriage. It is performed from week 11 onwards.
3. What chromosomal abnormalities can be detected by NACE?
NACE is a complete non-invasive prenatal test. It includes examinations to detect abnormalities in chromosomes 21, 18 and 13 (Down’s, Edwards and Patau syndromes).
It also includes an examination for the most common abnormalities in sex chromosomes (X and Y).
Furthermore, the NACE technology allows us to obtain information about additional alterations on other chromosomes, by analyzing the complete set of chromosomes.
4. Should I take the Igenomix NACE test?
The NACE test is recommended for all women who want to rule out the presence of the most common chromosomal alterations in the foetus, without putting their pregnancy at risk.
The test is especially suitable for women with a high risk of chromosomal abnormalities after 1st trimester screening (scan and hormonal analysis) who have had a previous Down’s syndrome pregnancy or following the detection of suspicious abnormalities in the ultrasounds.