ERA
Endometrial Receptivity Analysis

The ERA test helps avoid implantation failure by establishing the best day for embryo transfer

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ERA

Endometrial receptivity is essential for successful implantation

What is the endometrium?

What is
the endometrium?

What is endometrial receptivity?

What is
endometrial receptivity?

What is  the window of implantation?

What is
the window of implantation?

What is  a displaced window of implantation?

What is a displaced window of implantation?

Advanced Reproductive Genetic Services

Overview

  • Using a small sample of endometrial tissue the ERA test establishes the best day for transferring the embryo.
  • The biopsy sample is easily and quickly taken by your gynaecologist during your appointment.
  • ERA will determine if the endometrium is receptive or not at the time of sampling, by analysing 248 genes involved in endometrial receptivity.
  • ERA testing can find your personalized WOI in case of displacement, and will allow a personalized embryo transfer (pET).
Who should use ERA test?

Who should use ERA test?

The ERA test is recommended for:

  • Patients who have suffered recurrent implantation failure with quality embryos.
  • Patient who had implantation failure even with normal morphological endometrium.
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Benefits

Benefits

  • When performing the embryo transfer in a personalised way, the chances of getting pregnant are increased after the assisted reproductive treatment.
  • The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.

     

    *Ruiz-Alonso et al, Fertil Steril. 2013
    Clemente-Ciscar et al, 2018, submitted

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How it works

How it works

Results will be delivered in 15 working days after receiving the samples in our lab.

Downloads & publications

Scientific publications and documents.

ERA publications

ERA publications

Other scientific documents

Other scientific documents

What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study.
Hum Reprod. 2014 Jun;29(6):1244-7. doi: 10.1093/humrep/deu070. Epub 2014 Apr 15. PubMed PMID: 24737781.
Ruiz-Alonso M, Galindo N, Pellicer A, Simón C.

A Genomic Diagnostic Tool for Human Endometrial Receptivity based on the Transcriptomic Signature.
Fertil Steril.2011. 95(1)pp: 50-60, 60.e1-15
Díaz-Ginemo P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C

The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure..
Fertil Steril. 2013 Sep;100(3):818-24. doi: 10.1016/j.fertnstert.2013.05.004. Epub 2013 Jun 4.PubMed [journal]PMID:23756099
Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.

The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity..
Fertil Steril. 2013 Feb;99(2):508-17. doi: 10.1016/j.fertnstert.2012.09.046. Epub 2012 Oct 23
Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alamá P, Garrido N, Pellicer A, Simón C.

Endometrial receptivity array: Clinical application.

Mahajan N.
J Hum Reprod Sci.2015 Jul-Sep;8(3):121-9. doi: 10.4103/0974-1208.165153. PMID: 26538853 [PubMed] PMCID: PMC4601169. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26538853

Human Endometrial Transcriptomics: Implications for Embryonic Implantation.

Gómez E, Ruíz-Alonso M, Miravet J, Simón C.
Cold Spring Harb Perspect Med. 2015 Mar 27. pii: a022996. doi: 10.1101/cshperspect.a022996. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/?term=Human+Endometrial+Transcriptomics%3A+Implications+for+Embryonic+Implantation

The genomics of the human endometrium.

Ruiz-Alonso M, Blesa D, Simón C.
Biochim Biophys Acta. 2012 Dec;1822(12):1931-42.
http://www.ncbi.nlm.nih.gov/pubmed/22634130

Profiling the gene signature of endometrial receptivity: clinical results.

Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C.
Fertil Steril. 2013 Mar 15;99(4):1078-85.
http://www.ncbi.nlm.nih.gov/pubmed/23312228

Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression.

Bermejo A, Cerrillo M, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, Garcia-Velasco JA.
Fertil Steril. 2014 Jan;101(1):138-146.e3.
http://www.ncbi.nlm.nih.gov/pubmed/24182413

The impact of using the combined oral contraceptive pill for cycle scheduling on gene expression related to endometrial receptivity.

Bermejo A, Iglesias C, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, García-Velasco J.
Hum Reprod. 2014 Jun;29(6):1271-8. doi: 10.1093/humrep/deu065. Epub 2014 Apr 4.
http://www.ncbi.nlm.nih.gov/pubmed/24706003

Clinical management of endometrial receptivity.

Blesa D, Ruiz-Alonso M, Simón C.
Semin Reprod Med. 2014 Sep;32(5):410-3. doi: 10.1055/s-0034-1376360. Epub 2014 Jun 24.
http://www.ncbi.nlm.nih.gov/pubmed/24959823

Transcriptomics of the human endometrium.

Díaz-Gimeno P, Ruíz-Alonso M, Blesa D, Simón C.
Int J Dev Biol. 2014;58(2-4):127-37. doi: 10.1387/ijdb.130340pd.
http://www.ncbi.nlm.nih.gov/pubmed/25023678

Timing the window of implantation by nucleolar channel system prevalence matches the accuracy of the endometrial receptivity analysis.

Nejat EJ, Ruiz-Alonso M, Simón C, Meier UT.
Fertil Steril. 2014 Sep 17. pii: S0015-0282(14)02025-1. doi: 10.1016/j.fertnstert.2014.07.1254.
http://www.ncbi.nlm.nih.gov/pubmed/25241377

Deciphering the proteomic signature of human endometrial receptivity

Hum Reprod. 2014 Sep;29(9):1957-67. doi: 10.1093/humrep/deu171. Epub 2014 Aug 8
http://www.ncbi.nlm.nih.gov/pubmed/25106620

 

Success stories

“Without the ERA testing, we would not have our beautiful daughter Abigail. She is the light of our lives – and we are having so much fun."

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