SAT
Sperm Aneuploidy Test

Analysis of sperm chromosomal abnormalities

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Overview

  • SAT is a diagnostic test to study the genetic etiology of male infertility.
  • It allows us to evaluate the presence of an abnormal number of chromosomes in the sperm.
  • In couples with severe male factor infertility, there is a higher risk of transmission of sperm chromosomal abnormalities to the offspring.

More Info

Overview

Benefits

  • Increases pregnancy rate.
  • Decreases miscarriage risk.
  • Identify males with a low chance of reproductive success.
  • Useful tool to provide personalized genetic counseling to the infertile couple previous to an IVF treatment.

In couples with an abnormal SAT, it is indicated to perform PGS (Preimplantation Genetic Screening) to select chromosomally normal embryos for transfer.*
*Rodrigo et al., 2014.

Indications

  • Male factor infertility: low sperm concentration is correlated with a higher incidence of sperm chromosomal abnormalities.
  • Recurrent miscarriage of unknown etiology.
  • Repetitive implantation failure.
  • Previous pregnancy with a chromosomal abnormality.
Indications

Methodology

Methodology

Turn Around Time after receiving the samples in our laboratory: 3-4 weeks

Downloads & publications

Brochure

Brochure

Step by Step Provider

Step by Step Provider

 

Results

An increase of sperm chromosomal abnormalities affects reproduction on 3 levels.

EMBRYO LEVEL

  • Sperm with sex chromosomal abnormalities results in aneuploid embryos.
  • Diploid sperm result in triploid embryos.

(Rodrigo et al., 2010)

PREGNANCY LEVEL

  • An elevated SAT decreases pregnancy rates after ICSI.
  • And increases miscarriage rate.

(Rubio et al., 2001)

OFFSPRING LEVEL

  • It increases the risk of abnormal offspring for the chromosomes detected in the sperm (Down, Klinefelter or Turner's Syndromes)

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