When trying to conceive, both the embryo and the uterus are critical to implantation and pregnancy. For implantation to be successful, and the lining of the uterus (endometrium) and the quality of embryos should be in a good state. There are many couple who are deprived of the joy of parenthood due to a displaced window of implantation.
Get your facts cleared about the implantation window and endometrial receptivity with the following frequently asked questions on Endometrial Receptivity Analysis (ERA).
What is ERA test?
The ERA is a personalized genetic test to diagnose the state of endometrial receptivity in the window of implantation. This technique helps evaluate the woman’s endometrial receptivity from a molecular perspective.
What is the use of ERA test?
The ERA test is used to assess endometrial status and to determine whether or not the patient’s endometrium had a receptive gene profile at the time of biopsy.
The analysis reveals the personalized window of implantation of each woman. This data will enable a personalized embryo transfer (pET), synchronizing endometrial receptivity with a blastocyst prepared for implantation and further increases your chances of successful pregnancy.
For whom the ERA Test meant for?
ERA test has been performed on patients who have had repetitive implantation failure (RIF) with embryos of good morphological quality. This test is recommended for patients with a seemingly normal uterus and normal endometrial thickness (≥6 mm), in which no problems are detected.
The ERA test can also be performed in patients with an atrophic endometrium, whose thickness never reaches 6 mm consistently. However, if a patient with normal endometrial thickness presents a punctual cycle with growth below 6mm Igenomix recommend canceling the cycle and starting a new one.
Why do I need ERA?
ERA determines the personalized window of implantation of each patient before she begins an assisted reproductive treatment. ERA test increases the chances of pregnancy by 24% in women over 38 years old.
The ERA test has proven highly sensitive and accurate in detecting gene expression profiles associated with receptivity.
When to perform the ERA test?
The ERA Endometrial receptivity analysis should be performed during a HRT cycle or natural cycle. The receptivity diagnosis is valid just for the type of cycle during which the test is performed, therefore, the embryo transfer must be carried out in the same kind of cycle with which the receptive result is obtained.
What is the technology used for ERA Test?
The ERA test is presently performed by Next Generation Sequencing (NGS) technology. Before NGS, ERA test was performed using microarray. The change in technology used in ERA, from Arrays to NGS, not only upsurges the sampling volume to be processed, but it also suggests the development of a new and better predictor, which has allowed to improve the effectiveness of the analysis and to add other additional tests.
