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Endometrial liquid biopsy to predict endometrial receptivity

1 November, 2017

Endometrial liquid biopsy to predict endometrial receptivity

A new non-invasive method to predict endometrial receptivity using endometrial liquid biopsy.

  • The study was led by Prof. Carlos Simon and first author Dr. Felipe Vilella. Here the authors consider the use of endometrial fluid instead of traditional invasive biopsies, for a non-invasive and consequently painless diagnosis of endometrial receptivity and other applications such as the microbiome.
  • Until now, an endometrial biopsy was required to analyse endometrial receptivity, by analysing the transcriptome of the endometrium, to personalize embryo transfer.
  • This new methodology broadens the possibility of developing new endometrial tests using the same sample and opens the door to the possibility of performing personalized embryo transfer in the same cycle as the sample is taken.


  • With this technique, both endometrial cells and bacterial cells can be analyzed to predict the endometrial receptivity and endometrial microbiome.

This methology, applied to niERA (Non-invasive ERA test) will have some specific benefits:

  • Patients will benefit from this unique biopsy by saving time and resources, reducing emotional and physical discomfort.
  • In the near future, it is possible that embryo transfer could be performed in the same cycle as the endometrial fluid sample was retrieved.

Clinical application

Once the new technique is mastered by each clinician, the endometrial liquid biopsy will be ready to use in the niERA test (non-invasive ERA)and EMMA (Endometrial microbiome metagenomic analysis)

  • Our ERA test, now performed on endometrial fluid.
  • The same information in a gentle and non-invasive experience for your patients.
  • IGENOMIX continued focus on the endometrium has led to a new ERA test.
  • Sample collection is easy and quick, just a few microliters of endometrial fluid allows us to perform the test.

  • One step further on endometrial status analysis.
  • EMMA studies the endometrial microbiome profile and adds information of the patient’s reproductive prognosis.
  • 50% of infertile women had a low abundance of Lactobacillus in the uterus, which is linked to a poor reproductive outcome according to pilot study.*

*Moreno et al., AM J Obstet Gynecol, 2016; 215:684-703.


How to perform an Endometrial liquid biopsy