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New Age Genetic Techniques Boost IVF Success Rates

The new age reproductive genetic techniques have a drastic impact on success rates of IVF treatments. Studies say only one in 4 IVF cycles are successful. However, this success rate can be seen drastically improved by incorporating genetic techniques at various stages of IVF treatments- from embryos to implantations.

Synchrony, the new product by Igenomix synergizes the advantage of Endometrial Receptivity Analysis (ERA) and Preimplantation Genetic Screening (PGS) to help IVF specialists achieve a successful pregnancy for their patients.

The success of IVF depends on a lot of factors such as the age of the woman, the quality of the embryo, status of the uterus etc. But the two principal factors to consider maximizing the chances of implantation during an IVF treatment are a chromosomally normal embryo and a receptive endometrium.

Analysing and detecting the window of implantation is extremely important so as to prevent implantation failures. Due to lack of accurate methods of assessment, endometrial receptivity (ER) is not usually investigated in an infertile patient or even before in-vitro fertilization (IVF).

Endometrial tissue is a receptive lining in the uterus which is integral for successful pregnancy. Since long, endometrial tissue was checked through ultrasound. ERA is the latest discovery and technique to assess the endometrial receptivity.

It is a state-of-the-art diagnostic method, developed and patented by Igenomix in 2009. The development of this diagnostic technique is backed by 10 years of research. ERA establishes whether the woman is receptive on the day, when the biopsy is performed. If the result is positive then that is the window of implantation for that particular patient.

Even post a successful implantation there are many cases where the pregnancy ends up in a miscarriage in the first trimester itself. This mostly occurs due to chromosomal abnormalities in the embryo. Over 50% of spontaneous miscarriages are caused by chromosomal abnormalities.

IGENOMIX’s PGS with its added advantage of MitoScore boosts pregnancy rate by 70-80% by a single embryo transfer. PGS utilizes the latest next generation sequencing (NGS) technology to screen the embryos for chromosomal abnormalities of all 24 chromosomes, hence increasing the chances of conception by 60% through IVF.

New study from the Department of Obstetrics and Gynaecology, University of British Columbia, Children’s and Women’s Hospital and the Health Centre of British Columbia confirms that Synchrony (ERA + PGS) increase the effectiveness of IVF treatments.

In order to prove the effectiveness of the endometrial receptivity analysis (ERA), the researchers followed 88 cases and used the embryo study through the preimplantation genetic screening (PGS), which prevented the results from suffering the influence of chromosomal changes of the embryo.

The study results shows:

  • Fertility depends largely on the embryo, but not on it alone, because despite the increase in success rates, 1/3 of the chromosomally analysed embryos do not implant, which shows that there is much more behind the mechanism of implantation of the embryo
  • The expression of endometrial receptivity is not a cause of infertility, but rather a characteristic to be considered to identify the patient’s implantation window (WOI).
  • In the natural fertility cycle, the implantation window is a period that lasts 4-5 days and is orchestrated by a series of hormonal factors that must be synchronized.

If both embryo and endometrium are synchronized, the IVF clinician can transfer the right embryo at the right time. Hence combining IGENOMIX ERA and PGS, facilitates in covering the two key factors to achieve your goal, a healthy baby at home.